THUNK – 83. CRISPR & Genetic Engineering
THUNK – 83. CRISPR & Genetic Engineering
CRISPR is making big waves in biology, and for good reason; the doors to genetic engineering are now wide open.
QUICK ADDENDUM: The CRISPR method is currently only used to modify germline genomes (fertilized eggs), not fully-grown organisms. (That’s why I stress the “new humans” angle.) We have methods to achieve that sort of modification (viruses mostly), but CRISPR just lets us rewrite one DNA at a time really really efficiently.
SECOND ADDENDUM: I said in this episode that high IQ is correlated with depression. This is a highly contentious statement, with no compelling evidence. However, there are good reasons to believe that high IQ is related to bipolar disorder: http://sengifted.org/archives/articles/the-impact-of-giftedness-on-psychological-well-being
-Links for the Curious-
This video is only possible because my amazing sister put together a summary of CRISPR that I could wrap my head around. They’re available here – http://imgur.com/a/PIvv5
A fantastic compilation of CRISPR/Cas9 papers – http://wwwuser.cnb.csic.es/~montoliu/…
A Reddit AMA from Paul Knoepfler, one of the pioneers of CRISPR – https://www.reddit.com/r/science/comm…
A Nature article on the newly-formed “biohacker” amateur genetics movement – http://www.nature.com/news/biohackers…
- CRISPR rivals put patents aside to help in fight against Covid-19 – STAT
- CRISPR 2.0: Base Editing in the Groove – Genetic Engineering & Biotechnology News
- The Promises of CRISPR Genome Editing in Biomedicine – Labiotech.eu
- The Code Breaker and Crispr People — the ethics of editing humanity – Financial Times
- ERS Genomics Licenses CRISPR Patents to CRO ZeClinics – GenomeWeb
- The Dark Side of CRISPR – Scientific American
- ERS Genomics and ZeClinics Sign CRISPR/Cas9 License Agreement – BioSpace
- Scientists Use CRISPR To Create Model of AML Progression – AJMC.com Managed Markets Network
- DECODR app identifies DNA mutations from CRISPR gene therapies – European Pharmaceutical Review
- CRISPR/Cas technology as a promising weapon to combat viral infections – Wiley
- Neanderthal-like ‘mini-brains’ created in lab with CRISPR – Nature.com
- Affordable CRISPR app reveals unintended mutations at site of CRISPR gene repair – Phys.org
- Affordable CRISPR app reveals unintended mutations at site of CRISPR gene repair – EurekAlert
- New CRISPR tech targets human genome’s complex code: Programmable CRISPR/Cas9-based kinase offers insights into, control over regulatory histone proteins – Science Daily
- After ditching Editas, AbbVie taps Caribou for new CRISPR, CAR-T pact – FierceBiotech
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