Posted by on January 25, 2018 12:53 am
Categories: Crispr

Genetically Modified Humans? CRISPR/Cas 9 Explained

This week Reactions dives into your DNA with the science and chemistry behind CRISPR/Cas 9. Fans of Blade Runner have already caught a glimpse of world with super-powered humans secretly living among us, capable of physical feats far beyond your everyday person. But now, with the the CRISPR/CAS9 Gene editing system, are we looking at a future with real replicants? Check out this video to get an inside look at how CRISPR works, and the sorts of wild medical advances that are on the horizon.

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Producer: Kirk Zamieroski

Writers: Megan Cartwright & Kirk Zamieroski

Executive Producer:
Adam Dylewski

Scientific consultants:
Chase Biesel, Ph.D
Martin Jinek, Ph.D.
Kyle Nackers

Roberto Daglio – Mr. Fantastic
Sam Leopard – Back for More


Video interviews with Jennifer Doudna:

Notes from CRISPR talk by Françoise Baylis at AAAS:

Addgene. CRISPR/Cas9 Guide. Web:

Addison et al. 2015. Gene Editing and Germ-line Intervention: The Need for Novel Responses to Novel Technologies. Molecular Therapy. Web:

Barrangou et al. 2007. CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes. Science. Web:

BBC. 1 February 2016. Scientists get ‘gene editing’ go-ahead. Web:

Chen et al. 2015. Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9. Human Molecular Genetics. Web:

Deltcheva et al. 2011. CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III. Nature. Web:

Guo et al. 2015. Targeted genome editing in primate embryos. Cell Research. Web:

Jansen et al. 2002. Identification of genes that are associated with DNA repeats in prokaryotes. Molecular Microbiology. Web:

Jinek et al. 2012. A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity. Science. Web:

Komor et al. 2016. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature. Web:

Liang et al. 2015. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein & Cell. Web:

MIT Technology Review. 11 February 2014. Genome Surgery. Web:

MIT Technology Review. 5 March 2015. Engineering the Perfect Baby. Web:

Nature. 1 April 2015. Mini enzyme moves gene editing closer to the clinic. Web:

Nature. 29 September 2015. Gene-edited ‘micropigs’ to be sold as pets at Chinese institute. Web:

Nature. CRISPR, the disruptor. 3 June 2015. Web:

Science. 17 December 2015. And Science’s 2015 Breakthrough of the Year is… Web:

The Verge. 20 April 2016. Breakthrough method means CRISPR just got a lot more relevant to human health. Web:

Melissa L. Hefferin, Alan E. Tomkinson, Mechanism of DNA double-strand break repair by non-homologous end joining, DNA Repair, Volume 4, Issue 6, 8 June 2005, Pages 639-648, ISSN 1568-7864,

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