Gene Splicing: Supercomputer Modeling Reveals Acrobatics of CRISPR-Cas9 Technology
Gene Splicing: Supercomputer Modeling Reveals Acrobatics of CRISPR-Cas9 Technology
Cas9 Enzyme Approaching DNA, with the CRISPR Region in Red. The CRISPR-Cas9 system is emerging as a transformative genome-editing tool. Here, Palermo et al. report the first biophysical study – based on multi-microsecond atomistic simulations – that details the conformational plasticity of the endonuclease Cas9 and its interplay with the nucleic acids. The study reveals a striking flexibility of the nuclease domain HNH as an essential element for its repositioning during the catalysis, while the non-target DNA strand is identified to be key in favoring the formation of a catalytically competent Cas9.
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- CRISPR 2.0: Base Editing in the Groove – Genetic Engineering & Biotechnology News
- The Promises of CRISPR Genome Editing in Biomedicine – Labiotech.eu
- The Code Breaker and Crispr People — the ethics of editing humanity – Financial Times
- ERS Genomics Licenses CRISPR Patents to CRO ZeClinics – GenomeWeb
- The Dark Side of CRISPR – Scientific American
- ERS Genomics and ZeClinics Sign CRISPR/Cas9 License Agreement – BioSpace
- Scientists Use CRISPR To Create Model of AML Progression – AJMC.com Managed Markets Network
- DECODR app identifies DNA mutations from CRISPR gene therapies – European Pharmaceutical Review
- CRISPR/Cas technology as a promising weapon to combat viral infections – Wiley
- Neanderthal-like ‘mini-brains’ created in lab with CRISPR – Nature.com
- Affordable CRISPR app reveals unintended mutations at site of CRISPR gene repair – Phys.org
- Affordable CRISPR app reveals unintended mutations at site of CRISPR gene repair – EurekAlert
- New CRISPR tech targets human genome’s complex code: Programmable CRISPR/Cas9-based kinase offers insights into, control over regulatory histone proteins – Science Daily
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