Posted by on July 16, 2020 12:15 am
Categories: Uncategorized

unexpected mutations, CRISPR-Cas9 applications is still a long way to go

CRISPR and the DNA fragment

according to the American“physics organizations”web site reported, local time, the United States“physics organizations” The website reported, from Columbia University, the Francis Crick Institute and the American Oregon Health and Science University, three independent research teams found that the CRISPR-Cas9 gene editing system may lead to the genome of the accidental mutation.

related papers have been published in the bioRxivpre print server is waiting for peer review.

in these three independent studies, scientists used the CRISPR-Cas9 gene editing system repair on fetal development have a significant impact on the mutation, known blinding mutations and known to cause heart problems of the mutations in these three cases, the target point is found near to several unexpected mutant loci.

in recent years, scientists have been in laboratory animals using CRISPR-Cas9 gene editing technology to test in humans the safe use of the possibilities. Medical scientists hope that this technology can be used to repair cause health problems embryonic mutations, some people even think that there might one day technology can be used to improve people’s certain capabilities.

unfortunately, the CRISPR-Cas9 gene editing technique in experimental animals has produced mixed results: in many cases, the disease-causing mutation has been repaired, the embryo can grow up healthy to adulthood. This technology is far better than the expected accuracy: not only the presence of“off-target”effect, and sometimes cutting the genome in unexpected ways repair. Because of these problems, current technology does not allow for humanity.

scientists have been hoping the entire gene editing system in the human body work better. It is worth noting that, in conducting such studies before, the researcher must from the government to get permission and at the end of the study after the destruction of all embryos, the embryo can not exceed the prescribed culture period.

the scientific community the original series: The Flower manuscript review: Seamus editor: Cheng Jian LAN

log source: bioRxiv

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Published at Thu, 16 Jul 2020 04:15:46 +0000